Like Shelley Duvall as Olive Oyl, this is the role she was born to play. But everyone else in it is pretty spot-on perfect too, as is the writing. Daria is one of those shows that I think works even better as a '90s snapshot than it did as contemporary commentary at the time, so the class reunion device is also exactly right as a way to do it.
C'mon, MTV and Paramount - make this happen for real. I'm serious. Let Zach Braff Kickstarter it if you have to. He'll pick all the bands you're hyping right now for the soundtrack.
If you're not familiar with Daria, this is the actual show. The College Humor trailer is after the jump: